Genetic Manipulation of Leishmania donovani to Explore the Involvement of Argininosuccinate Synthase in Oxidative Stress Management.

• Main Authors: Abul Hasan Sardar (Author), Armando Jardim (Author), Ayan Kumar Ghosh (Author), Abhishek Mandal (Author), Sushmita Das (Author), Savita Saini (Author), Kumar Abhishek (Author), Ruby Singh (Author), Sudha Verma (Author), Ajay Kumar (Author), Pradeep Das (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Reactive oxygen and nitrogen species (ROS and RNS) produced by the phagocytic cells are the most common arsenals used to kill the intracellular pathogens. However, Leishmania, an intracellular pathogen, has evolved mechanisms to survive by counterbalancing the toxic oxygen metabolites produced durin...