Analogues of 2'-hydroxychalcone with modified C4-substituents as the inhibitors against human acetylcholinesterase

• Main Authors: Sri Devi Sukumaran (Author), Shah Bakhtiar Nasir (Author), Jia Ti Tee (Author), Michael J. C. Buckle (Author), Rozana Othman (Author), Noorsaadah Abd. Rahman (Author), Vannajan Sanghiran Lee (Author), Syed Nasir Abbas Bukhari (Author), Chin Fei Chee (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of C4-substituted tertiary nitrogen-bearing 2'-hydroxychalcones were designed and synthesised based on a previous mixed type acetylcholinesterase inhibitor. Majority of the 2'-hydroxychalcone analogues displayed a better inhibition against acetylcholinesterase (AChE) than butyrylc...