Alleviation of endoplasmic reticulum stress protects against cisplatin-induced ovarian damage

• Main Authors: Yuping Wu (Author), Congshun Ma (Author), Huihui Zhao (Author), Yuxia Zhou (Author), Zhenguo Chen (Author), Liping Wang (Author)
• Format: Book
• Published: BMC, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cisplatin (CDDP), a widely used chemotherapeutic agent, can induce excessive granulosa cell apoptosis, follicle loss and even premature ovarian insufficiency (POI). However, the mechanism remains elusive, although some studies have indicated the involvement of endoplasmic reticul...