Clinical evaluation of modifications to a human papillomavirus assay to optimise its utility for cervical cancer screening in low-resource settings: a diagnostic accuracy study

• Main Authors: Louise Kuhn, ProfPhD (Author), Rakiya Saidu, MPH (Author), Rosalind Boa, MBChB (Author), Ana Tergas, MD (Author), Jennifer Moodley, ProfPhD (Author), David Persing, MD (Author), Scott Campbell, PhD (Author), Wei-Yann Tsai, ProfPhD (Author), Thomas C Wright, ProfMD (Author), Lynette Denny, ProfPhD (Author)
• Format: Book
• Published: Elsevier, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Background: HPV-based screen and treat is the recommended approach for cervical cancer screening in low-resource settings, but quite low specificity of human papillomavirus (HPV) testing, particularly in women living with HIV, leads to overtreatment. We evaluated whether HPV type restrictio...