Dendritic nanomedicine enhances chemo-immunotherapy by disturbing metabolism of cancer-associated fibroblasts for deep penetration and activating function of immune cells

• Main Authors: Yunkun Li (Author), Xiaoding Shen (Author), Haitao Ding (Author), Yuxin Zhang (Author), Dayi Pan (Author), Liping Su (Author), Yahui Wu (Author), Zaixiang Fang (Author), Jie Zhou (Author), Qiyong Gong (Author), Kui Luo (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inefficient drug penetration hurdled by the stroma in the tumor tissue leads to a diminished therapeutic effect for drugs and a reduced infiltration level of immune cells. Herein, we constructed a PEGylated dendritic epirubicin (Epi) prodrug (Epi-P4D) to regulate the metabolism of cancer-associated...