BACHD Mice Recapitulate the Striatal Parvalbuminergic Interneuron Loss Found in Huntington's Disease

• Main Authors: Vyshnavi Rallapalle (Author), Annesha C. King (Author), Michelle Gray (Author)
• 格式: 圖書
• 出版: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Huntington's disease (HD) is a dominantly inherited, adult-onset neurodegenerative disease characterized by motor, psychiatric, and cognitive abnormalities. Neurodegeneration is prominently observed in the striatum where GABAergic medium spiny neurons (MSN) are the most affected neuronal popula...