Population Pharmacokinetic/Pharmacodynamic Analysis of the DPP-4 Inhibitor Linagliptin in Japanese Patients with Type 2 Diabetes Mellitus

• Main Authors: Yusuke Tadayasu (Author), Akiko Sarashina (Author), Yasuhiro Tsuda (Author), Shinji Tatami (Author), Christian Friedrich (Author), Silke Retlich (Author), Alexander Staab (Author), Mikihisa Takano (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

[Objectives] Linagliptin is a novel, highly selective and long acting DPP-4 inhibitor for the treatment of type 2 diabetes mellitus (T2DM). Linagliptin exhibits non-linear pharmacokinetics (PK) due to saturable binding to plasma and tissue DPP-4. The aim of this study was to characterize the PK and...