Optimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of Osteoarthritis

• Egile Nagusiak: Laurie R Goodrich (Egilea), Jennifer N Phillips (Egilea), C Wayne McIlwraith (Egilea), Stacey B Foti (Egilea), Joshua C Grieger (Egilea), Steven J Gray (Egilea), R Jude Samulski (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2013-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Osteoarthritis (OA) affects over 40 million people annually. We evaluated interleukin-1 receptor antagonist (IL-1ra) gene transfer in an equine model based on IL-1ra protein therapy which inhibits inflammation through blocking IL-1. Using the self-complementary adeno-associated virus (scAAV)IL-1ra e...