Optimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of Osteoarthritis

Optimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of Osteoarthritis

Osteoarthritis (OA) affects over 40 million people annually. We evaluated interleukin-1 receptor antagonist (IL-1ra) gene transfer in an equine model based on IL-1ra protein therapy which inhibits inflammation through blocking IL-1. Using the self-complementary adeno-associated virus (scAAV)IL-1ra e...

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Bibliographic Details
Main Authors: Laurie R Goodrich (Author), Jennifer N Phillips (Author), C Wayne McIlwraith (Author), Stacey B Foti (Author), Joshua C Grieger (Author), Steven J Gray (Author), R Jude Samulski (Author)
Format: Book
Published: Elsevier, 2013-01-01T00:00:00Z.
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3rd Floor Main Library

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