Case Report: IL-21 and Bcl-6 Regulate the Proliferation and Secretion of Tfh and Tfr Cells in the Intestinal Germinal Center of Patients With Inflammatory Bowel Disease
Objective: This study aimed to investigate the effect of interleukin (IL)-21 and B cell lymphoma protein-6 on germinal center follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells and its relationship with the clinical features of inflammatory bowel disease (IBD).Methods: The expre...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Book |
| Published: |
Frontiers Media S.A.,
2021-01-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_37ecd438d6b7468cb5d3a8b37092aae7 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Youguang Yang |e author |
| 700 | 1 | 0 | |a Xiaodan Lv |e author |
| 700 | 1 | 0 | |a Lingling Zhan |e author |
| 700 | 1 | 0 | |a Lan Chen |e author |
| 700 | 1 | 0 | |a Hui Jin |e author |
| 700 | 1 | 0 | |a Xinping Tang |e author |
| 700 | 1 | 0 | |a Qingqing Shi |e author |
| 700 | 1 | 0 | |a Qiyuan Zou |e author |
| 700 | 1 | 0 | |a Jiqiao Xiang |e author |
| 700 | 1 | 0 | |a WeiWei Zhang |e author |
| 700 | 1 | 0 | |a Zhaojing Zeng |e author |
| 700 | 1 | 0 | |a Haixing Jiang |e author |
| 700 | 1 | 0 | |a Xiaoping Lv |e author |
| 245 | 0 | 0 | |a Case Report: IL-21 and Bcl-6 Regulate the Proliferation and Secretion of Tfh and Tfr Cells in the Intestinal Germinal Center of Patients With Inflammatory Bowel Disease |
| 260 | |b Frontiers Media S.A., |c 2021-01-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2020.587445 | ||
| 520 | |a Objective: This study aimed to investigate the effect of interleukin (IL)-21 and B cell lymphoma protein-6 on germinal center follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells and its relationship with the clinical features of inflammatory bowel disease (IBD).Methods: The expression of peripheral blood cytokines IL-21 and Bcl-6 mRNA was detected by reverse transcription-polymerase chain reaction. The distribution characteristics of Tfh and Tfr cells were detected using the triple immunofluorescence staining analysis.Results: The expression of IL-21 and Bcl-6 mRNA was upregulated in the ulcerative colitis (UC) and Crohn disease (CD) groups compared with that in the control group. Triple immunofluorescence staining showed that the number of Tfh cells in the intestinal germinal center obviously increased in the UC and CD groups compared with that in the control group, whereas the number of Tfr cells reduced.Conclusion: This study suggested that the Tfr and Tfh cells might be involved in the regulation of IBD. Bcl-6 and IL-21 can regulate the Tfh/Tfr ratio in the intestinal germinal center, promoting the occurrence and development of IBD. | ||
| 546 | |a EN | ||
| 690 | |a Bcl-6 | ||
| 690 | |a follicular helper T cells | ||
| 690 | |a follicular regulatory T cells | ||
| 690 | |a germinal center | ||
| 690 | |a IL-21 | ||
| 690 | |a inflammatory bowel disease | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 11 (2021) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2020.587445/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/37ecd438d6b7468cb5d3a8b37092aae7 |z Connect to this object online. |