Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis

• Main Authors: Toshihisa Ishikawa (Author), Hiroshi Nakagawa (Author), Yuichiro Hagiya (Author), Naosuke Nonoguchi (Author), Shin-ichi Miyatake (Author), Toshihiko Kuroiwa (Author)
• Format: Book
• Published: Hindawi Limited, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Accumulating evidence indicates that ATP-binding cassette (ABC) transporter ABCG2 plays a key role in regulating the cellular accumulation of porphyrin derivatives in cancer cells and thereby affects the efficacy of photodynamic therapy and photodynamic diagnosis. The activity of porphyrin efflux ca...