An engineered human IgG1 CH2 domain with decreased aggregation and nonspecific binding

• প্রধান লেখক: Guangcan Cao (লেখক), Xinyu Gao (লেখক), Yancheng Zhan (লেখক), Qingguang Wang (লেখক), Zhe Zhang (লেখক), Dimiter S. Dimitrov (লেখক), Rui Gong (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

The immunoglobulin (Ig) CH2 domain is a promising scaffold for the development of candidate therapeutics. We have previously shown that the stability of isolated CH2 could be increased by the introduction of an additional disulfide bond and removal of seven N-terminal residues (m01s). However, both...