IRAK4 Deficiency in a Patient with Recurrent Pneumococcal Infections: Case Report and Review of the Literature

• Main Authors: Karina Gobin (Author), Mary Hintermeyer (Author), Bertrand Boisson (Author), Maya Chrabieh (Author), Pegah Ghandil (Author), Anne Puel (Author), Capucine Picard (Author), Jean-Laurent Casanova (Author), John Routes (Author), James Verbsky (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Primary immunodeficiencies are genetic defects of the innate or adaptive immune system, resulting in a propensity to infections. The innate immune system is the first line of defense against pathogens and is critical to recognize microbes and start the inflammatory cascade. Sensing of microbes occur...