Activation of PERK/eIF2α/ATF4/CHOP branch of endoplasmic reticulum stress response and cooperation between HIF-1α and ATF4 promotes Daprodustat-induced vascular calcification

• Hauptverfasser: Andrea Tóth (Verfasst von), Gréta Lente (Verfasst von), Dávid Máté Csiki (Verfasst von), Enikő Balogh (Verfasst von), Árpád Szöőr (Verfasst von), Béla Nagy (Verfasst von), Viktória Jeney (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Introduction: Vascular calcification is accelerated in patients with chronic kidney disease (CKD) and increases the risk of cardiovascular events. CKD is frequently associated with anemia. Daprodustat (DPD) is a prolyl hydroxylase inhibitor for the treatment of CKD-associated anemia that enhances er...