Discovery of new chromen-4-one derivatives as telomerase inhibitors through regulating expression of dyskerin

• Glavni autori: Jie Quan Wang (Autor), Meng Di Yang (Autor), Xing Chen (Autor), Yang Wang (Autor), Liu Zeng Chen (Autor), Xiu Cheng (Autor), Xin Hua Liu (Autor)
• Format: Knjiga
• Izdano: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

A series of new trimethoxyphenyl-4H-chromen derivatives as telomerase inhibitors through regulation dyskerin were designed and synthesised. The anticancer activity assay in vitro showed that compound 5i 3-(4-(4-isonicotinoylpiperazin-1-yl)butoxy)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4...