Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain

• Main Authors: Vanderah Todd W (Author), Nelson Mark A (Author), Chandramouli Anupama (Author), Okun Alec (Author), Sukhtankar Devki (Author), Cress Anne E (Author), Porreca Frank (Author), King Tamara (Author)
• Format: Book
• Published: SAGE Publishing, 2011-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Mechanisms driving cancer-induced bone pain are poorly understood. A central factor implicated to be a key player in the process of tumorigenesis, osteoclastogenesis and nociception is p38 MAPK. We determined the role of p38 MAPK in...