Interleukin‐6 promotes skeletal muscle catabolism by activating tryptophan-indoleamine 2,3‐dioxygenase 1-kynurenine pathway during intra‐abdominal sepsis

• Main Authors: Tingbin Xie (Author), Tengfei Lv (Author), Tenghui Zhang (Author), Dengyu Feng (Author), Feng Zhu (Author), Yi Xu (Author), Liang Zhang (Author), Lili Gu (Author), Zhen Guo (Author), Chao Ding (Author), Jianfeng Gong (Author)
• Format: Book
• Published: Wiley, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Inflammatory cytokine interleukin‐6 (IL‐6) plays a pivotal role in skeletal muscle degradation after intra‐abdominal sepsis (IAS), with mechanism remained to be elucidated. Indoleamine 2,3‐dioxygenase 1 (IDO‐1), a key enzyme in converting tryptophan into kynurenine, could be acti...