Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension

• Main Authors: Raffaele Altara (Author), Romain Harmancey (Author), Sean P Didion (Author), George W. Booz (Author), Fouad Zouein (Author), Fouad A Zouein (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Signal transducer and activator of transcription 3 (STAT3) protects the heart from acute ischemic stress. However, the importance of STAT3 to the heart in chronic stress, such as hypertension, is not known. To study this, we used cardiomyocyte-targeted STAT3 knockout (KO) mice and ANG II infusion by...