Periorbital Nociception in a Progressive Multiple Sclerosis Mouse Model Is Dependent on TRPA1 Channel Activation

• Main Authors: Diéssica Padilha Dalenogare (Author), Camila Ritter (Author), Fernando Roberto Antunes Bellinaso (Author), Sabrina Qader Kudsi (Author), Gabriele Cheiran Pereira (Author), Maria Fernanda Pessano Fialho (Author), Débora Denardin Lückemeyer (Author), Caren Tatiane de David Antoniazzi (Author), Lorenzo Landini (Author), Juliano Ferreira (Author), Guilherme Vargas Bochi (Author), Sara Marchesan Oliveira (Author), Francesco De Logu (Author), Romina Nassini (Author), Pierangelo Geppetti (Author), Gabriela Trevisan (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Headaches are frequently described in progressive multiple sclerosis (PMS) patients, but their mechanism remains unknown. Transient receptor potential ankyrin 1 (TRPA1) was involved in neuropathic nociception in a model of PMS induced by experimental autoimmune encephalomyelitis (PMS-EAE), and TRPA1...