Berberine Suppresses Lung Metastasis of Cancer via Inhibiting Endothelial Transforming Growth Factor Beta Receptor 1

• Main Authors: Wenjia Tian (Author), Huifeng Hao (Author), Ming Chu (Author), Jingjing Gong (Author), Wenzhe Li (Author), Yuan Fang (Author), Jindong Zhang (Author), Cunzheng Zhang (Author), Yonghui Huang (Author), Fei Pei (Author), Liping Duan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study investigated the effects of berberine (BBR) on pancreatic cancer (PC) lung metastasis and explored the underlying mechanisms, using a BALB/C-nu/nu nude mouse model injected with PC cells (AsPC-1). Intragastric administration of BBR dose-dependently improves survival of mice intravenously...