Applying machine learning to the pharmacokinetic modeling of cyclosporine in adult renal transplant recipients: a multi-method comparison

• Main Authors: Junjun Mao (Author), Yuhao Chen (Author), Luyang Xu (Author), Weihuang Chen (Author), Biwen Chen (Author), Zhuo Fang (Author), Weiwei Qin (Author), Mingkang Zhong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The aim of this study was to identify the important factors affecting cyclosporine (CsA) blood concentration and estimate CsA concentration using seven different machine learning (ML) algorithms. We also assessed the predictability of established ML models and previously built population...