Protein Kinase A-Dependence of the Supraspinally Mediated Analgesic Effects of Gabapentin on Thermal and Mechanical Hypersensitivity

Abstract.: We have recently shown that gabapentin generates protein kinase A (PKA)-dependent presynaptic inhibition of GABAergic synaptic transmission in locus coeruleus (LC) neurons only under neuropathic states. To verify behaviorally this in vitro electrophysiological finding, the PKA inhibitor H...

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Main Authors: Keiko Takasu (Author), Yu Kinoshita (Author), Hideki Ono (Author), Mitsuo Tanabe (Author)
Format: Book
Published: Elsevier, 2009-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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