Inclusion of the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances AAV2-Driven Transduction of Mouse and Human Retina

• Những tác giả chính: Maria I. Patrício (Tác giả), Alun R. Barnard (Tác giả), Harry O. Orlans (Tác giả), Michelle E. McClements (Tác giả), Robert E. MacLaren (Tác giả)
• Định dạng: Sách
• Được phát hành: Elsevier, 2017-03-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

The woodchuck hepatitis virus posttranscriptional regulatory element (WPRE) has been included in the transgene cassette of adeno-associated virus (AAV) in several gene therapy clinical trials, including those for inherited retinal diseases. However, the extent to which WPRE increases transgene expre...