A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat

• Main Authors: Yulia A. Sidorova (Author), Maxim M. Bespalov (Author), Agnes W. Wong (Author), Oleg Kambur (Author), Viljami Jokinen (Author), Tuomas O. Lilius (Author), Ilida Suleymanova (Author), Gunnar Karelson (Author), Pekka V. Rauhala (Author), Mati Karelson (Author), Peregrine B. Osborne (Author), Janet R. Keast (Author), Eija A. Kalso (Author), Mart Saarma (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neuropathic pain caused by nerve damage is a common and severe class of chronic pain. Disease-modifying clinical therapies are needed as current treatments typically provide only symptomatic relief; show varying clinical efficacy; and most have significant adverse effects. One approach is targeting...