The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis

Objective: Non-alcoholic steatohepatitis (NASH) is characterized by hepatic steatosis, inflammation and fibrosis. There are currently no targeted therapies for NASH. We developed a liver-specific LXR inverse agonist, SR9238, which effectively reduces hepatic lipogenesis in models of obesity and hepa...

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Prif Awduron: Kristine Griffett (Awdur), Ryan D. Welch (Awdur), Colin A. Flaveny (Awdur), Grant R. Kolar (Awdur), Brent A. Neuschwander-Tetri (Awdur), Thomas P. Burris (Awdur)
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Cyhoeddwyd: Elsevier, 2015-04-01T00:00:00Z.
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