Effective targeting of microglial P2X7 following intracerebroventricular delivery of nanobodies and nanobody-encoding AAVs

• Main Authors: Carolina Pinto-Espinoza (Author), Charlotte Guillou (Author), Björn Rissiek (Author), Maximilian Wilmes (Author), Ehsan Javidi (Author), Nicole Schwarz (Author), Marten Junge (Author), Friedrich Haag (Author), Nastassia Liaukouskaya (Author), Nicola Wanner (Author), Annette Nicke (Author), Catelijne Stortelers (Author), Yossan-Var Tan (Author), Sahil Adriouch (Author), Tim Magnus (Author), Friedrich Koch-Nolte (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The P2X7 ion channel is a key sensor for extracellular ATP and a key trigger of sterile inflammation. Intravenous injection of nanobodies that block P2X7 has shown to be beneficial in mouse models of systemic inflammation. P2X7 has also emerged as an attractive therapeutic target for inflammatory br...