Pharmacokinetics and exposure-safety relationship of ciprofol for sedation in mechanically ventilated patients in the intensive care unit

• Main Authors: Lu Liu (Author), Kun Wang (Author), Zhongyi Sun (Author), Pangke Yan (Author), Mengyue Hu (Author), Xiao Liu (Author), Meixia Chen (Author), Nan Wu (Author), Xiaoqiang Xiang (Author)
• Format: Book
• Published: Wiley, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Ciprofol (HSK3486) is a newly developed, highly selective γ‐aminobutyric acid‐A (GABAA) receptor potentiator that is recently approved for a new indication of sedation for patients in the intensive care unit (ICU) in China. This analysis aimed to characterize the population pharmacokinetics...