Synthesis and biological evaluation of histamine Schiff bases as carbonic anhydrase I, II, IV, VII, and IX activators

• Päätekijät: Suleyman Akocak (Tekijä), Nabih Lolak (Tekijä), Daniela Vullo (Tekijä), Mustafa Durgun (Tekijä), Claudiu T. Supuran (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

A series of 20 histamine Schiff base was synthesised by reaction of histamine, a well known carbonic anhydrase (CA, E.C 4.2.2.1.) activator pharmacophore, with substituted aldehydes. The obtained histamine Schiff bases were assayed as activators of five selected human (h) CA isozymes, the cytosolic...