Plumbagin rescues the granulosa cell's pyroptosis by reducing WTAP-mediated N6-methylation in polycystic ovary syndrome

Abstract The survival of ovary granulosa cells (GC) is critical in the initiation and progression of polycystic ovary syndrome (PCOS) in females. Here, we found that the PCOS process is accompanied by massive GC pyroptosis resulting from Caspase-1 inflammasome activation. Administration of plumbagin...

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Main Authors: Zhaowei Cai (Author), Shaojuan He (Author), Rongju Liu (Author), Liling Zhou (Author), Li Zhao (Author)
Format: Book
Published: BMC, 2022-12-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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