Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER-ERK-NF-κB signaling pathway

• Main Authors: Zining Yu (Author), Guangjun Su (Author), Limei Zhang (Author), Gaigai Liu (Author), Yonggang Zhou (Author), Shicai Fang (Author), Qian Zhang (Author), Tianyun Wang (Author), Cheng Huang (Author), Zhihua Huang (Author), Liangdong Li (Author)
• Format: Book
• Published: BMC, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Activated microglia play a key role in initiating the inflammatory cascade following ischemic stroke and exert proinflammatory or anti-inflammatory effects, depending on whether they are polarized toward the M1 or M2 phenotype. The present study investigated the regulatory effect...