Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER-ERK-NF-κB signaling pathway

• المؤلفون الرئيسيون: Zining Yu (مؤلف), Guangjun Su (مؤلف), Limei Zhang (مؤلف), Gaigai Liu (مؤلف), Yonggang Zhou (مؤلف), Shicai Fang (مؤلف), Qian Zhang (مؤلف), Tianyun Wang (مؤلف), Cheng Huang (مؤلف), Zhihua Huang (مؤلف), Liangdong Li (مؤلف)
• التنسيق: كتاب
• منشور في: BMC, 2022-11-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract Background Activated microglia play a key role in initiating the inflammatory cascade following ischemic stroke and exert proinflammatory or anti-inflammatory effects, depending on whether they are polarized toward the M1 or M2 phenotype. The present study investigated the regulatory effect...