Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism

• Main Authors: Daniel Ferguson (Author), Sophie J. Eichler (Author), Nicole K.H. Yiew (Author), Jerry R. Colca (Author), Kevin Cho (Author), Gary J. Patti (Author), Trevor M. Shew (Author), Andrew J. Lutkewitte (Author), Sandip Mukherjee (Author), Kyle S. McCommis (Author), Natalie M. Niemi (Author), Brian N. Finck (Author)
• Format: Book
• Published: Elsevier, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The mitochondrial pyruvate carrier (MPC) has emerged as a therapeutic target for treating insulin resistance, type 2 diabetes, and nonalcoholic steatohepatitis (NASH). We evaluated whether MPC inhibitors (MPCi) might correct impairments in branched chain amino acid (BCAA) catabolism, whic...