Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism

Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism

Objective: The mitochondrial pyruvate carrier (MPC) has emerged as a therapeutic target for treating insulin resistance, type 2 diabetes, and nonalcoholic steatohepatitis (NASH). We evaluated whether MPC inhibitors (MPCi) might correct impairments in branched chain amino acid (BCAA) catabolism, whic...

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Main Authors: Daniel Ferguson (Author), Sophie J. Eichler (Author), Nicole K.H. Yiew (Author), Jerry R. Colca (Author), Kevin Cho (Author), Gary J. Patti (Author), Trevor M. Shew (Author), Andrew J. Lutkewitte (Author), Sandip Mukherjee (Author), Kyle S. McCommis (Author), Natalie M. Niemi (Author), Brian N. Finck (Author)
Format: Book
Published: Elsevier, 2023-04-01T00:00:00Z.
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3rd Floor Main Library

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