Exploitation of De Novo Helper-Lipids for Effective Gene Delivery.

• Main Authors: Tomoaki Kurosaki (Author), Takashi Kitahara (Author), Mugen Teshima (Author), Koyo Nishida (Author), Junzo Nakamura (Author), Mikiro Nakashima (Author), Hideto To (Author), Hiromitsu Hukuchi (Author), Tomoyuki Hamamoto (Author), Hitoshi Sasaki (Author)
• Format: Book
• Published: Frontiers Media S.A., 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: In gene delivery, a fusogenic lipid such as dioleyl phosphatidylethanolamine (DOPE) which is a component of cationic liposomal vector is important factor for effective transfection efficiency. We investigated the effect of penetration enhancers as alternative helper-lipids to DOPE. Methods:...