Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages

• Main Authors: Baoyuan Huang (Author), Qiumei Wang (Author), Lin Jiang (Author), Shuru Lu (Author), Chengcheng Li (Author), Chunqi Xu (Author), Caiyan Wang (Author), Enxin Zhang (Author), Xiaojun Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dysregulated immune response plays a pivotal role in Ulcerative colitis. In lamina propria of inflammatory colonic mucosa, macrophages tend to polarize into M1 type and metabolically reprogram to aerobic glycolysis. PKM2 orchestrates glucose metabolic switch in macrophages, which tetramer has high p...