Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders

• Main Authors: Wataru Araki (Author), Kotaro Hattori (Author), Kazutomi Kanemaru (Author), Yuma Yokoi (Author), Yoshie Omachi (Author), Harumasa Takano (Author), Masuhiro Sakata (Author), Sumiko Yoshida (Author), Tadashi Tsukamoto (Author), Miho Murata (Author), Yuko Saito (Author), Hiroshi Kunugi (Author), Yu-ichi Goto (Author), Utako Nagaoka (Author), Masahiro Nagao (Author), Takashi Komori (Author), Kunimasa Arima (Author), Kenji Ishii (Author), Shigeo Murayama (Author), Hiroshi Matsuda (Author), Hisateru Tachimori (Author), Yumiko M. Araki (Author), Hidehiro Mizusawa (Author)
• Format: Book
• Published: BMC, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Because soluble (or secreted) amyloid precursor protein-β (sAPPβ) and -α (sAPPα) possibly reflect pathological features of Alzheimer's disease (AD), they are potential biomarker candidates for dementia disorders, including AD and mild cognitive impairment (MCI) due to AD (MC...