Effect of Oxygen and Water on the Stability of Imipenem and Cilastatin Sodium for Injection

• Main Authors: Meng Zhang (Author), Chun-Feng Liu (Author), Xiao-Yan Chen (Author), Li-Na Yang (Author), Chun-Mei Zhu (Author), Jian-Hao Teng (Author), Hao-Xiang Wu (Author), Fu-Li Zhang (Author)
• Format: Book
• Published: Georg Thieme Verlag KG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The study aimed to investigate the factors affecting the stability of imipenem and cilastatin sodium for injection (IMI/CIL) to improve the quality and stability in IMI/CIL preparation. In this study, the effects of headspace oxygen (HO), water content, particle shape, and particle size on the stabi...