UCP2 deficiency helps to restrict the pathogenesis of experimental cutaneous and visceral leishmaniosis in mice.

• Main Authors: Javier Carrión (Author), M Angeles Abengozar (Author), María Fernández-Reyes (Author), Carlos Sánchez-Martín (Author), Eduardo Rial (Author), Gustavo Domínguez-Bernal (Author), M Mar González-Barroso (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Uncoupling protein 2 (UCP2) is a mitochondrial transporter that has been shown to lower the production of reactive oxygen species (ROS). Intracellular pathogens such as Leishmania upregulate UCP2 and thereby suppress ROS production in infected host tissues, allowing the multiplication of parasites w...