UCP2 deficiency helps to restrict the pathogenesis of experimental cutaneous and visceral leishmaniosis in mice.

• Главные авторы: Javier Carrión (Автор), M Angeles Abengozar (Автор), María Fernández-Reyes (Автор), Carlos Sánchez-Martín (Автор), Eduardo Rial (Автор), Gustavo Domínguez-Bernal (Автор), M Mar González-Barroso (Автор)
• Формат: ‌
• Опубликовано: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Uncoupling protein 2 (UCP2) is a mitochondrial transporter that has been shown to lower the production of reactive oxygen species (ROS). Intracellular pathogens such as Leishmania upregulate UCP2 and thereby suppress ROS production in infected host tissues, allowing the multiplication of parasites w...