Ponatinib: A Review of the History of Medicinal Chemistry behind Its Development

• Main Authors: Mayara Nascimento (Author), Stefany Moura (Author), Lidia Parra (Author), Valeska Vasconcellos (Author), Gabriela Costa (Author), Debora Leite (Author), Maria Dias (Author), Tácio Vinício Amorim Fernandes (Author), Lucas Hoelz (Author), Luiz Pimentel (Author), Monica Bastos (Author), Nubia Boechat (Author)
• Format: Book
• Published: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The primary treatment for chronic myeloid leukemia (CML) involves first- and second-generation tyrosine kinase inhibitors (TKIs), such as imatinib, nilotinib, bosutinib, and dasatinib. However, these medications are ineffective against mutations in the kinase domain of the ABL1 protein, particularly...