Repression of the iron exporter ferroportin may contribute to hepatocyte iron overload in individuals with type 2 diabetes

• Main Authors: Ruiyue Qiu (Author), Kristina Alikhanyan (Author), Nadine Volk (Author), Oriana Marques (Author), Christina Mertens (Author), Anand Ruban Agarvas (Author), Sanjana Singh (Author), Rainer Pepperkok (Author), Sandro Altamura (Author), Martina U. Muckenthaler (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Hyperferremia and hyperferritinemia are observed in patients and disease models of type 2 diabetes mellitus (T2DM). Likewise, patients with genetic iron overload diseases develop diabetes, suggesting a tight link between iron metabolism and diabetes. The liver controls systemic iron homeo...