Effect of the Phosphodiesterase 5 Inhibitor Sildenafil on Ischemia-Reperfusion-Induced Muscle Mitochondrial Dysfunction and Oxidative Stress

• Main Authors: Liliane Tetsi (Author), Anne-Laure Charles (Author), Isabelle Georg (Author), Fabienne Goupilleau (Author), Anne Lejay (Author), Samy Talha (Author), Myriam Maumy-Bertrand (Author), Claire Lugnier (Author), Bernard Geny (Author)
• Format: Book
• Published: MDPI AG, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lower-limb ischemia-reperfusion (IR) is frequent and associated with significant morbidity and mortality. Phosphodiesterase 5 inhibitors demonstrated antioxidant and beneficial effects in several organs submitted to IR, but their effects on muscle mitochondrial functions after lower-limb IR are unkn...