Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons

• Main Authors: Silvia Claros (Author), Pablo Cabrera (Author), Nadia Valverde (Author), Silvana Y. Romero-Zerbo (Author), Manuel Víctor López-González (Author), Kirill Shumilov (Author), Alicia Rivera (Author), Jose Pavia (Author), Elisa Martín-Montañez (Author), María Garcia-Fernandez (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Stress seems to contribute to Parkinson's disease (PD) neuropathology, probably by dysregulation of the hypothalamic-pituitary-adrenal axis. Key factors in this pathophysiology are oxidative stress and mitochondrial dysfunction and neuronal glucocorticoid-induced toxicity. The insulin-like grow...