Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons

• Hoofdauteurs: Silvia Claros (Auteur), Pablo Cabrera (Auteur), Nadia Valverde (Auteur), Silvana Y. Romero-Zerbo (Auteur), Manuel Víctor López-González (Auteur), Kirill Shumilov (Auteur), Alicia Rivera (Auteur), Jose Pavia (Auteur), Elisa Martín-Montañez (Auteur), María Garcia-Fernandez (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2021-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Stress seems to contribute to Parkinson's disease (PD) neuropathology, probably by dysregulation of the hypothalamic-pituitary-adrenal axis. Key factors in this pathophysiology are oxidative stress and mitochondrial dysfunction and neuronal glucocorticoid-induced toxicity. The insulin-like grow...