Celecoxib and rofecoxib have different effects on small intestinal ischemia/reperfusion injury in rats

• Main Authors: Szilvia B. László (Author), Barbara Hutka (Author), András S. Tóth (Author), Tamás Hegyes (Author), Zsuzsanna O. Demeter (Author), Arezoo Haghighi (Author), Gerda Wachtl (Author), Ágnes Kelemen (Author), Anna Jakab (Author), Klára Gyires (Author), Zoltán S. Zádori (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionIntestinal ischemia/reperfusion (I/R) injury is associated with high mortality and there is an unmet need for novel therapies. The intestinal expression of cyclooxygenase-2 (COX-2) increases rapidly after mesenteric I/R, but it is still a question of debate whether selective COX-2 inhibi...