Pharmacogenomics Biomarker Discovery and Validation for Translation in Clinical Practice

• Main Authors: Mariamena Arbitrio (Author), Francesca Scionti (Author), Maria Teresa Di Martino (Author), Daniele Caracciolo (Author), Licia Pensabene (Author), Pierfrancesco Tassone (Author), Pierosandro Tagliaferri (Author)
• Format: Book
• Published: Wiley, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interindividual variability in drug efficacy and toxicity is a major challenge in clinical practice. Variations in drug pharmacokinetics (PKs) and pharmacodynamics (PDs) can be, in part, explained by polymorphic variants in genes encoding drug metabolizing enzymes and transporters (absorption, distr...