Effect of Compaction Pressure on the Enzymatic Activity of Pancreatin in Directly Compressible Formulations

• Main Authors: Daniel Zakowiecki (Author), Peter Edinger (Author), Tobias Hess (Author), Jadwiga Paszkowska (Author), Marcela Staniszewska (Author), Svitlana Romanova (Author), Grzegorz Garbacz (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tableting of biomolecules is a challenging formulation phase due to their sensitivity to various process parameters, such as compression pressure, process dynamics, or the temperature generated. In the present study, pancreatin was employed as a model enzyme mixture, which was formulated in tablet f...