Development of a Biphasic-Release Multiple-Unit Pellet System with Diclofenac Sodium Using Novel Calcium Phosphate-Based Starter Pellets

• Main Authors: Daniel Zakowiecki (Author), Maja Frankiewicz (Author), Tobias Hess (Author), Krzysztof Cal (Author), Maciej Gajda (Author), Justyna Dabrowska (Author), Bartlomiej Kubiak (Author), Jadwiga Paszkowska (Author), Marcela Wiater (Author), Dagmara Hoc (Author), Grzegorz Garbacz (Author), Dorota Haznar-Garbacz (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Novel calcium phosphate-based starter pellets were used to develop a biphasic-release multiple-unit pellet system (MUPS) with diclofenac sodium as a model drug in the form of hard gelatin capsules. For comparative purposes, corresponding formulations based on the inert cores made of microcrystalline...