Assessment of HIF-1α expression and release following endothelial injury in-vitro and in-vivo

• Autori principali: Lamia Heikal (Autore), Pietro Ghezzi (Autore), Manuela Mengozzi (Autore), Gordon Ferns (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2018-05-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background Endothelial injury is an early and enduring feature of cardiovascular disease. Inflammation and hypoxia may be responsible for this, and are often associated with the up-regulation of several transcriptional factors that include Hypoxia Inducible Factor-1 (HIF-1). Although it has...