A physiologically-based pharmacokinetic model of oseltamivir phosphate and its carboxylate metabolite for rats and humans

• 主要な著者: Guanghua Gao (著者), Francis Law (著者), Ricky Ngok Shun Wong (著者), Nai Ki Mak (著者), Mildred Sze Ming Yang (著者)
• フォーマット: 図書
• 出版事項: International Association of Physical Chemists (IAPC), 2019-02-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Oseltamivir phosphate (OP, Tamiflu®) is a widely used prodrug for the treatment of influenza viral infections. Orally administered OP is rapidly hydrolyzed by the carboxylesterases in animals to oseltamivir carboxylate (OC), a potent influenza virus neuraminidase inhibitor. The goals of this study w...