The Role of Uptake and Efflux Transporters in the Disposition of Glucuronide and Sulfate Conjugates

• Główni autorzy: Erkka Järvinen (Autor), Feng Deng (Autor), Wilma Kiander (Autor), Alli Sinokki (Autor), Heidi Kidron (Autor), Noora Sjöstedt (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Glucuronidation and sulfation are the most typical phase II metabolic reactions of drugs. The resulting glucuronide and sulfate conjugates are generally considered inactive and safe. They may, however, be the most prominent drug-related material in the circulation and excreta of humans. The glucuron...