The Anticancer Effects of the Pro-Apoptotic Benzofuran-Isatin Conjugate (5a) Are Associated With p53 Upregulation and Enhancement of Conventional Chemotherapeutic Drug Efficiency in Colorectal Cancer Cell Lines

• Main Authors: Mansoor-Ali (Author), Maha-Hamadien Abdulla (Author), Sabine Matou-Nasri (Author), Wagdy M. Eldehna (Author), M. Meeramaideen (Author), Eslam B. Elkaeed (Author), Mohammed El-Watidy (Author), Noura S. Alhassan (Author), Khayal Alkhaya (Author), Omar Al Obeed (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Fag: article
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The present study aimed to investigate in-depth a cytotoxic novel benzofuran-isatin conjugate (5a, 3-methyl-N'-(2-oxoindolin-3-ylidene)benzofuran-2-carbohydrazide) with promising potential anticancer activities in colorectal adenocarcinoma HT29 and metastatic colorectal cancer (CRC) SW620 cell...