Angiotensin II Type I Receptor Agonistic Autoantibody Induces Podocyte Injury via Activation of the TRPC6- Calcium/Calcineurin Pathway in Pre-Eclampsia

• Main Authors: Ying Yu (Author), Lihong Zhang (Author), Guang Xu (Author), Zhenghong Wu (Author), Qian Li (Author), Yong Gu (Author), Jianying Niu (Author)
• Format: Book
• Published: Karger Publishers, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Angiotensin II type I receptor agonistic autoantibody (AT1-AA) is closely related to pre-eclampsia, which is characterized by proteinuria and hypertension. AT1-AA has been shown to enhance the effect of AngII in pre-eclampsia, such as production of endothelin-1, activation of ROS, a...