5-Aryl-1,3,4-oxadiazol-2-amines Decorated with Long Alkyl and Their Analogues: Synthesis, Acetyl- and Butyrylcholinesterase Inhibition and Docking Study

• Váldodahkkit: Václav Pflégr (Dahkki), Šárka Štěpánková (Dahkki), Katarína Svrčková (Dahkki), Markéta Švarcová (Dahkki), Jarmila Vinšová (Dahkki), Martin Krátký (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2022-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

2,5-Disubstituted 1,3,4-oxadiazoles are privileged versatile scaffolds in medicinal chemistry that have exhibited diverse biological activities. Acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors are used, e.g., to treat dementias and myasthenia gravis. 5-Aryl-1,3,4-oxadiazoles decorated wit...