Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy

• Main Authors: Yuqin Yao (Author), Zhuowei Liu (Author), Manyu Zhao (Author), Zhengxia Chen (Author), Peng Li (Author), Yang Zhang (Author), Yuxi Wang (Author), Chengjian Zhao (Author), Chaofeng Long (Author), Xiaoxin Chen (Author), Jinliang Yang (Author)
• Format: Book
• Published: Elsevier, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Angiokinases, such as vascular endothelial-, fibroblast- and platelet-derived growth factor receptors (VEGFRs, FGFRs and PDGFRs) play crucial roles in tumor angiogenesis. Anti-angiogenesis therapy using multi-angiokinase inhibitor has achieved great success in recent years. In this study, we present...